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KMID : 0359420060240020164
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Korean Journal of Sports Medicine
2006 Volume.24 No. 2 p.164 ~ p.169
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The natural History of the Anterior Cruciate Ligament-Reconstructed Knee: Changes in Synovial Fluid Cytokine Concentrations
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Kyung Hee-Soo
Kim Shin-Yoon
Oh Chang-Wug
Kim Hee-Soo
Choi Jae-Yong
Noh Jung-Ho
Park Seung-Ki
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Abstract
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The purpose of our study was to determine the concentrations of cytokine profiles in the chronic ACL-deficient knee and reconstructed knee. Nineteen patients, who were undertaken ACL reconstruction using patellar tendon autograft, were enrolled. Group A(n=4) was normal contralateral knee. Group B(n=10) was pure ACL-deficient knee. Group C(n=9) was ACL-deficient and cartilage injured knee. Group D(n=10) was pure ACL-reconstructed knee. Group E(n=9) was ACL-reconstructed and debridement & partial meniscectomized knee. Joint fluid from group B and C was obtained at post-trauma 3 months, group D and E at post-operation one year. IL-1β, TNF-α, IL-6 and MMP-3 was analyzed using ELISA. TNF-α, IL-1β, MMP-3, IL-6 was higher concentration in ACL-deficient knee than normal knee. ACL-deficient and cartilage damaged knee had higher concentration of all 4 cytokines than pure ACL-deficient knee. IL-1β, TNF-α, IL-6 concentration in ACL-reconstructed knee was higher than normal, but decreased than ACL-deficient knee. MMP-3 concentration was decreased to nearly normal after ACL reconstruction. After ACL reconstruction the cytokine profile was approaching to normal, but not returned to normal after surgery one year. We need more cases and follow-up period to evaluate relationship between ACL-reconstructed knee and osteoarthritis.
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KEYWORD
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ACL deficient knee, ACL reconstruction, Cytokine
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